The aim of this project is to create a clinical score, based on the creation of a clinical score for diarrheal calves (Lorenz, 2004), to determine the degree of intoxication in peracute to acute mastitis in practice.

The clinically altered parameters can then be compared with the degree of intoxication and the severity of mastitis. Based on this, optimal therapy is initiated and recovery is monitored.

The grouping process determines which methods will enable the sick cow to resume eating most quickly and produce adequate milk, in order to minimize the farmer's losses as much as possible.

Coliomastitis is a medical emergency because this form of mastitis is a highly acute illness, and treatment is only promising within the first few hours. The inflammation and the effects of toxins either lead to the animal's death, or the animal survives this phase, but the udder returns to normal only very slowly, often not even within the same lactation. Without treatment, this disease has a high mortality rate.

The endotoxins released in large quantities during the fight against the pathogens are extremely toxic or even lethal to the host because they can trigger septic shock. The clinical picture and pathophysiology are very complex. The administration of a non-steroidal anti-inflammatory drug (NSAID), recommended in addition to any antibiotic treatment, has shown varying effects in several studies. Some clinical symptoms were improved by the additional therapy. Inflammatory markers in milk or during milk production showed both significant and non-significant changes. Grandemange et al. (2002) also suggested additional intravenous fluid therapy.

Hypertonic solutions increase plasma volume, boost heart output, and improve oxygen delivery to tissues.

The severity of intoxication cannot be determined using a single parameter. While the cause of mastitis can be identified through bacteriological milk examination, this alone does not provide information about the degree and extent of the inflammation. Using the data collected in this project and the development of a clinical score, the aim is to establish correlations and specific characteristics between the degree of intoxication, the severity of mastitis, and the clinical status.

By dividing the cows into three groups (no infusion, isotonic and hypertonic infusion), it is investigated whether infusions are necessary and, if so, in what concentration they are suitable to support the cow's recovery as part of the therapy.

Early optimal therapy is absolutely necessary in acute parenchymatous mastitis to prevent total losses and to achieve the fastest possible recovery (feeding and milk production).